M. Peters , D. Iber ,
 D-BSSE, ETH, Zurich, Switzerland
During growth, tissue expands and deforms. Given its elastic properties, stresses emerge in an expanding and deforming tissue. Cell rearrangements can dissipate these stresses and numerous experiments confirm the viscoelastic properties of tissues. On long time scales, as characteristic for many developmental processes, tissue is therefore typically represented as a liquid, viscous material and ...
R. Appali, S. Petersen, J. Gimsa, and U. Rienen
 Institute of General Electrical Engineering, Chair of Electromagnetic Field Theory, University of Rostock, Germany
 Institute of Biology, Chair of Biophysics, University of Rostock, Germany
Study of neurons plays a key role in the fields of basic and medical research aiming at the development of electrically active implants. The Fitzhugh-Nagumo equations are used to model and simulate the spike generation and propagation in a squid giant axon using COMSOL Multiphysics® 3.5a Software. It is shown that the Fitzhugh-Nagumo equations allow for a geometrical explanation of ...
An Assessment of the Suitability of the Body and Adult Head Coils for Transmission during Paediatric Magnetic Resonance Imaging
G.R. Cook, M.J. Graves, F.J. Robb, D.J. Lomas
Department of Radiology, University of Cambridge, Cambridge, United Kingdom
General Electric Healthcare Coils, Aurora, Ohio, USA
MRI offers many advantages over other modalities and its lack of ionizing radiation is important for children, but can be limited by the radio-frequency (RF) coils available. This work calculates Specific Absorption Rate (SAR) and homogeneity of the RF transmit field (B1+) when imaging infants in adult coils. Two birdcage-type coils were loaded by a tissue model and their B1+ homogeneities ...
A. Zare , E. Cutler , H. Cho ,
 Center for Biomedical Engineering & Science, University of North Carolina - Charlotte, Charlotte, NC, USA
INTRODUCTION: Researchers in the biomedical field have recently become interested in the potential applications of plasomics. Surface plasmon resonance based on optical properties of metallic nanostructures can be used for detection of special biological targets. Gold nanostructures with different shapes and sizes have been designed to achieve high enhancement factor (EF), wide range of ...
R. Penjweini, T. C. Zhu,
 Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA
Introduction: Type II photodynamic therapy (PDT) is an experimental modality for cancer treatment based on the combined action of a photosensitizing drug (photosensitizer), a special wavelength of light and singlet oxygen (1O2) generation; the cell killing is caused by the reaction of cellular acceptors with 1O2. A mathematical model has been previously developed to incorporate the macroscopic ...
Multiphysics Modeling of Cellular Arrays Using Periodic Minimal Surfaces – A Drug and Gene Delivery Application
J.I. Rey, A.J. Llewellyn, R.J. Connolly, J.P. Jimenez, A.M. Hoff, and R.A. Gilbert
University of South Florida, Tampa, FL, USA
Minimal surfaces are found in nature from crystalline structures to biological nano and micro structures such as biomembranes, and osseous formations in sea urchin. An application to electrically mediated drug and gene delivery is presented. Periodic level surfaces which approximate minimal surfaces are used to generate a geometric representation of tissue. A method to create such structures ...
R. De Luca[1,2], J. Fromageau, H.W. Chan, F. Marinozzi, J. Bamber
Institute of Cancer Research and Royal Marsden Hospital, Sutton, England, United Kingdom
Sapienza University of Rome, Dept. of Mechanical and Aerospace Engineering, Rome, Italy
Shear wave elastography is an innovative technique used in combination with the traditional ultrasound imaging to improve the specificity of cancer imaging. A two-dimensional finite element model (FEM), composed of realistic boundary conditions, was developed in COMSOL Multiphysics® to simulate the propagation of shear waves induced by an acoustic radiation force impulse (ARFI) in isotropic, ...
T. Suzuki, C. Holloway, S. Taylor
University College London, London, UK
Manual wheelchair users suffer shoulder pain and injury in the long term because of unconscious overuse. The ‘SENSEWHEEL’, which interposes three identical load cells between pushrim and rear wheel, measures the three components of pushing force Fx, Fy and Fz, and axial torque Tx applied at each load cell. Strain gauges were located on a diaphragm forming one face of the load cell. The ...
K. Gladine , J. Soons , J. Dirckx 
 University of Antwerp, Belgium
The ear doesn’t solely listen but it also speaks. Sounds formed in the inner ear which are measurable in the outer ear are called Otoacoustic emissions (OAEs). Some claim these are produced by the outer hair cells (OHCs), the amplifiers in the inner ear. Our hypothesis is that the OHCs only amplify distortion products (DPs) but do not produce them.
A Multiphysics Model of O2 Transport and Recirculation During Venovenous Extracorporeal Life Support
S. Conrad ,
 Louisiana State University Health Sciences Center, Shreveport, LA, USA
Venovenous extracorporeal life support (VV-ECLS) provides gas exchange support for severe lung failure by using an extracorporeal circuit consisting of a blood pump and an artificial membrane lung. Blood is withdrawn from a cannula placed into the inferior vena cava, and returned from the circuit into the superior vena cava, adding oxygen to and removing carbon dioxide from the venous blood. ...