See How Multiphysics Simulation Is Used in Research and Development

Engineers, researchers, and scientists across industries use multiphysics simulation to research and develop innovative product designs and processes. Find inspiration in technical papers and presentations they have presented at the COMSOL Conference. Browse the selection below or use the Quick Search tool to find a specific presentation or filter by application area.
View the COMSOL Conference 2018 Collection
Bioscience and Bioengineeringx

Modeling Interface Response in Cellular Adhesion

G. Megali[1], D. Pellicanò[1], M. Cacciola[1], F. Calarco[1], D. De Carlo[1], F. Laganà[1], and F.C. Morabito[1]

[1]DIMET Department, Faculty of Engineering, University “Mediterranea” of Reggio Calabria, Reggio Calabria, Italy

Constitutive properties of living cells are able to withstand physiological environment as well as mechanical stimuli occurring within and outside the body. We examined fluid flow and Neo-Hookean deformation related to the rolling effect. A mechanical model to describe the cellular ... Read More

Actively Controlled Ionic Current Gating In Nanopores

G. Zhang[1], S. Bearden[1]
[1]Clemson University, Clemson, SC, USA

It is necessary to understand and control nanopore behavior in order to develop biosensors for a variety of applications including DNA sequencing. The fluidics of nanopore devices we fabricated exhibits a range of interesting phenomena, such as enhanced conductance and current ... Read More

Fresh Produce Safety During Hydrocooling: An Engineering Model new

A. Warning[1], A. K. Datta[1]
[1]Department of Biological & Environmental Engineering, Cornell University, Ithaca, NY, USA

Hydrocooling is the process by which warm produce is chilled with water. The chilling of warm produce generates a negative pressure differential between the produce (warm) and (cold) water due to the condensation of water vapor inside the produce which forms a vacuum and can pull in ... Read More

Numerical Simulation of the Functional Electromagnetic Stimulation of the Human Femoral Bone using COMSOL

Y. Haba[1], W. Kröger[2], H. Ewald[2], R. Souffrant[1], W. Mittelmeier[1], and R. Bader[1]

[1]Biomechanics and Implant Technology Research Laboratory, Department of Orthopaedics, University of Rostock, Rostock, Germany
[2]Institute of General Electrical Engineering, University of Rostock, Rostock, Germany

In the present study we determined the relative conductivities and permittivities of fresh cortical and cancellous bone measuring human femoral heads in different slices of 1 mm thickness. The identified conductivities of human trabecular bone are used for the electromagnetic field ... Read More

Prediction of Time of Death Using a Heat Transport Model

J.L. Smart[1], and M. Kaliszan[2]
[1]University of Kentucky, Paducah, KY, USA
[2]Medical University of Gdansk, Gdansk, Poland

COMSOL Multiphysics® 4.0 was used to study conductive and convective heat transfer from the human eyeball to the surrounding air. Postmortem temperature decay curves were collected in eyeballs of numerous human corpses. Of course, these curves represent only a portion of the complete ... Read More

Simulations of Lateral Flow and Vertical Flow Microarray Assays for Point of Care Diagnostics new

G. E. Svedberg[1], L. Lama[1], J. Gantelius[1]
[1]Science for Life Laboratory, Stockholm, Sweden

Paper based lateral flow assays are widely used as point of care devices for disease diagnostics due to their low cost, short run time and ease of use. Binder molecules specific for certain molecular biomarkers of interest are typically deposited as dots or lines on paper strips, ... Read More

Thermal-Optical Modeling of a Signal Enhancement Approach for Paper-Based Diagnostics

D. Gasperino [1]
[1] Intellectual Ventures Laboratory, Bellevue, WA, USA

INTRODUCTION: Point of care diagnostics aimed at low-resource settings need to be relatively simple, robust and low-cost. The most commonly-used diagnostic platform in these settings is the lateral flow assay (LFA). LFAs are paper-based immunoassays designed to perform on-strip ... Read More

Using COMSOL Multiphysics® Software for Benchmarking Problems in Cell Migration

M. Nickaeen [1], I. L. Novak [1], A. Mogilner [2], B. M. Slepchenko [1],
[1] Richard D. Berlin Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, CT, USA
[2] Courant Institute and Department of Biology, New York University, New York, NY, USA

A recently published conservative algorithm for simulating reactions and transport in moving domains have been extended to models in which cell kinematics are coupled with intracellular dynamics. For this, the method that combines a Eulerian approach with tracking an explicit boundary ... Read More

Electroceutical Modeling with Advanced COMSOL® Techniques

K. Carlson [1,][2], J. Begnaud [3], J. L. Shils [4], S. Dokos [5], L. Mei [1,][2], J. E. Arle [1,][2]
[1] Beth Israel Deaconess Medical Center, Boston, MA, USA
[2] Harvard Medical School, Boston, MA, USA
[3] Livanova Neuromodulation, Houston, TX, USA
[4] Rush Medical Center, Chicago, IL, USA
[5] University of New South Wales, Sydney, NSW, Australia

Neuromodulation is the use of electromagnetic fields to modulate the human nervous system, typically to treat neurological disorders. Electroceuticals is an ambitious program to modulate any nerve, anywhere, anytime, for any reason — to treat disease, disorders, and enhance or interface ... Read More

Numerical Homogenization in Multi-scale Models of Musculoskeletal Mineralized Tissues

A. Gerisch[1], S. Tiburtius[1], Q. Grimal[2], and K. Raum[3]
[1]Technische Universität Darmstadt, Darmstadt, Germany
[2]Laboratoire d’Imagerie Paramétrique, UPMC, Paris, France
[3]Julius Wolff Institut & Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany

Musculoskeletal mineralized tissues (MMTs), e.g. bone, are hierarchical composite materials. Their effective elastic properties at different scales are of interest for computational studies of the MMT’s response to mechanical loading but also to realistically simulate implant ... Read More