Theoretical and Practical Approach for Transdermal Drug Delivery using Microneedle for Successful Skin Penetration
Jeevan J.Mahakud, Ziaur Reheman
Department of electronics and Communication engineering, Institute of technical education and research, Bhubaneswar, Odisha, India
Department of electronics and instrumentation engineering, Institute of technical education and research, Bhubaneswar, Odisha, India
With the advent of MEMS, transdermal drug delivery has been developed to increase skin permeability for drug transport. Various microneedle structures have been analyzed theoretically as well as through simulation using COMSOL Multiphysics®. Then computational fluid dynamics has been presented in order to study the behavior of the fluid flow inside the microneedle cavity. In this report, the ...
School of Mechanical Engineering, University of Birmingham, Birmingham, United Kingdom
A device for monitoring the oxygen consumption of cells has been developed, which consists of two parts; a cell culturing platform (CCP) and an oxygen sensing chip. The CCP possesses inlet and outlet pipes to direct the fluid under the test to the cell culturing chamber through the inlet pipe and goes out of the outlet pipe after being partially consumed by the cells. In this abstract, the ...
A. Warning , A. K. Datta ,
 Cornell University, Ithaca, NY, USA
The particle tracking model provided a deeper understanding to the experimental results. The model showed good agreement with experimental data for rotation, transport and attachment. In the attachment model, protrusions create low velocity, low shear regions increasing attachment while holes pull cells toward the surface and increase residence time on the surface increasing attachment rate.
E. Holzbecher ,
 German University of Technology in Oman (GUtech), Halban, Oman
A model for CO2 storage is presented. It is shown that the system is highly dynamic, i.e. results depend strongly on parameter disturbances and numerical features. However, a series of scenario calculations shows that there are invariants, most important: the duration of the early convection phase with high mass transfer rates.
X. Gong, R. Wan
University of Calgary, Calgary, AB, Canada
THM (Thermo-Hydro-Mechanical) behavior of the reservoir during SAGD (Steam-Assistant-Gravity-Drainage) was studied through a proper constitutive modeling of the porous media. Specifically, a generalized density-stress-fabric dependent elasto-plastic model with stress-dilatancy and plastic damage as main ingredients was implemented into COMSOL Multiphysics®, to model geomechanical behavior during ...
J. P. Wojeicchowski , A. P. Ramos , J. S. Sousa , L. G. Maciel , M. M. Pariona ,
 Universidade Estadual de Ponta Grossa, Ponta Grossa, PR, Brasil
 Universidad Peruana Unión, Juliaca, Peru
O objetivo deste trabalho foi modelar a perda de umidade de bananas Caturra com os modelos empíricos e com o software COMSOL Multiphysics, definindo os coeficientes convectivo de transferência de massa e difusivo. O valor obtido para coeficiente de difusão, com base no ajuste matemático da 2ª Lei de Fick para cilindros foi de 1,89.10-9 m²/s. O valor do coeficiente convectivo de transferência de ...
B. Suryawansi , B. Mohanty ,
 Indian Institute of Technology Roorkee, Uttarakhand, India.
In the present work, COMSOL Multiphysics® software was used to solve a mass transfer based mathematical model (Stastova et al., 1996) which is a modified form of Sovova H.,1994 model. The modification has been brought about by introducing the term ‘Grinding efficiency’ in the model and the results of the this model has been compared with the theoretical results obtained by Duba and Fiori, 2015 ...
V. Runkana, A. Pareek, P. Arora
Tata Consultancy Services, Pune, Maharashtra, India
Indian Institute of Technology Delhi, New Delhi, Delhi, India
Limited drug efficacy, undesirable temporal changes in drug concentration and patient non-compliance due to frequent dosing schedule have given impetus to design of controlled drug release systems . Biodegradable polymers due to their favorable and tunable properties and biocompatibility have found widespread use in the field of controlled drug delivery . Exploratory in vitro experiments ...
V. Sharma , S. Pramanik , M. Mishra ,
 Indian Institute of Technology Ropar, Rupnagar, India
 Indian Institute of Technology Ropar, Rupnagar, India; Nordita, SE-10691 Stockholm, Sweden.
COMSOL Multiphysics® software was used to model radial source flow in two dimensional homogeneous porous media. Two-Phase Darcy's Law (tpdl) is used to model miscible viscous fingering. Fingering patterns obtained on using different mesh are discussed. Evolution from 'flowers' to 'branches' is observed in the fingering patterns. Stable displacement is generated even in the presence of unstable ...
Rheological Behaviour of Single–Phase Non-Newtonian Polymer Solution in Complex Pore Geometry: A Simulation Approach
P. Idahosa, G. Oluyemi, R. Prabhu, B. Oyeneyin
IDEAS Research Institute/School of Engineering, Robert Gordon University, Aberdeen, United Kingdom.
School of Engineering, Robert Gordon University, Aberdeen, United Kingdom.
One of the most important criteria for evaluating chemical enhanced oil recovery (EOR) processes that use polymers is its rheological behaviour which in turn account for other physical effects of adsorption and resistance factors during polymer-rock interactions. However, complete knowledge of behaviour of polymer solution in porous media has not yet been fully gained. A computational fluid ...