Study of Fluid and Mass Adsorption Model in the QCM-D Sensor for Characterization of Biomolecular Interaction
H.J. Kwon, C.K. Bradfield, B.T. Dodge, and G.S. Agoki
Department of Engineering and Computer Science, Andrews University, Berrien Springs, Michigan, USA
Increasing attention has been paid to application of the quartz crystal microbalance with dissipation (QCM-D) sensor for monitoring biomolecular interactions. This paper focuses on a practical application of protein-protein binding affinity measurement at low concentrations and minimal sample sizes (50-200 μl of 20-200 nM), which results in low signal measurement. A model simulating fluid ...
A. Weddemann, A. Auge, F. Wittbracht, C. Albon, and A. Hütten
Department of Physics, Thin Films and Physics of Nanostructures, Bielefeld University, Bielefeld, Germany
In this work, we demonstrate the implementation of the micromagnetic equations for the description of ferromagnetic thin films in COMSOL Multiphysics®. We apply our model to magnetoresistive sensors consisting of several soft ferromagnetic layers and their response to magnetic particles. The magnetization dynamic of the particles needs to be described in a similar manner, though due to size ...
L. Wright, G. Memoli, P. Jones, E. Stride
National Physical Laboratory, Teddington, UK
University College London, London, UK
University of Oxford, Oxford, UK
Understanding the interactions between microbubbles and surfaces is key to the successful deployment of microbubbles in a range of applications. Two important examples are their use as a drug delivery mechanism, and their potential use of acoustically-driven bubbles as microscale sensors. Drug delivery with bubbles involves sonication at high frequency close to a boundary, and sensing with ...
A. Ivanov, U. Mescheder
Furtwangen University, Furtwangen, Germany
In the presented work the dynamic simulation of a silicon anodization process is performed. Two mechanisms of etch form development (diffusion in electrolyte, current flow) are considered and simulated. Influence of electrolyte conductivity and radius of the opening in the masking layer is discussed.
The Effects of the Electrical Double Layer on Giant Ionic Currents through Single Walled Carbon Nanotubes
G. Zhang[,][,], S.L. Bearden 
Department of Bioengineering, Clemson University, Clemson, SC, USA
Department of Electrical and Computer Engineering, Clemson University, Clemson, SC, USA
Institute for Biological Interfaces of Engineering, Clemson University, Clemson, SC, USA
Electrofluidic transport through a single walled carbon nanotube (SWCNT) is enhanced by electroosmosis. Electroosmosis is made possible in these devices by the combination of a large slip length within SWCNTs and the interfacial potential at the solution/nanotube interface. A computational model of a SWCNT device was developed using COMSOL Multiphysics to investigate the complete electrical ...
M. Weber, M. Reed
Yale University, New Haven, CT, USA
Arrays of vertical pillars, Micro Purification Chips, have been widely used for analyte capture from liquid samples [Henderson et. al, 2006], [Toner et. al, 2007], [Stern et. al, 2010]. However exact understanding of the capture efficiency mechanisms has not been previously explained. Here we present a model in COMSOL Multiphysics® which calculates analyte capture efficiency based on initial ...
3D-Modeling of Magnetophoretic Separation of Superparamagnetic Dispersions Using COMSOL Multiphysics® Particle Tracing Module
D. Kleinehanding, L. Teich, C. Schröder
Department of Engineering Sciences and Mathematics, Computational Materials Science & Engineering (CMSE), University of Applied Sciences Bielefeld, Bielefeld, Germany
Magnetophoresis is a process of great interest for novel applications based on magnetic nanoparticles and colloids. Environmental applications like wastewater treatments and pollutant removal, biomedical applications like protein isolation, drug delivery, magnetic hyperthermia for cancer treatment, and magnetic-particle imaging are just a few of the numerous technological areas which exploit the ...
The Origin of Mass-change Sensitivity within Multi-layered, Non-uniform, Piezoelectrically-actuated Millimeter-sized Cantilever (PEMC) Biosensors: Vibrational Analysis through Experiment and Finite Element Modeling (FEM)
B.N. Johnson, and R. Mutharasan
Department of Chemical and Biological Engineering, Drexel University, Philadelphia, Pennsylvania, USA
A 3D finite element model (FEM) of the PEMC sensor was developed to characterize the modes of vibration that have demonstrated high sensitivity to mass-change in experimentally fabricated sensors. The fundamental bending mode of vibration and the 1st bending harmonic are predicted at 10.0 kHz and 86.8 kHz, respectively, within approximately 5 % of the experimentally measured resonances. The ...
N. Das, C. R. Chaudhuri
Department of Electronics and Telecommunication, BESUS, Howrah, West Bengal, India
In this paper, we have proposed an impedance biosensor based on polymer nanowire (made of polyaniline) for efficient electric field mediated capture of biomolecules. Existing polymer nanowire based biosensors fail to achieve high sensitivity for low surface to volume ratio as the whole length of the nanowire is exposed to the analyte .Also biosensors are dependent on diffusion mediated capture ...
Modeling and Simulation of the Rapid and Automated Measurement of Biofuel Blending in a Microfluidic Device under Pressure Driven Flow using COMSOL Multiphysics®
Sanket Goel, Venkateswaran PS, Rahul Prajesh, Ajay Agarwal
University of Petroleum & Energy Studies, Bidholi, Prem Nagar, Dehradun, India
CSIR - Central Electronics Engineering Research Institute,(CSIR-CEERI) Pilani, India
• Real-time detection and monitoring of bio-fuel blend-ratio and adulterated automobile fuels by a reproducible micro-fabrication process in a cost-and-time efficient manner. • COMSOL Multiphysics® simulations and modelling of Viscosity based Laminar Flow inside a Y-shaped Micro-fluidic Device. • Design and Fabrication of a polymer Y-shaped Micro-fluidic Device to work as Micro-Viscometer for ...