See How Multiphysics Simulation Is Used in Research and Development

Engineers, researchers, and scientists across industries use multiphysics simulation to research and develop innovative product designs and processes. Find inspiration in technical papers and presentations they have presented at the COMSOL Conference. Browse the selection below or use the Quick Search tool to find a specific presentation or filter by application area.
View the COMSOL Conference 2018 Collection
Bioscience and Bioengineeringx

Comparison of Computational Methods for the Estimation of the Dielectrophoretic Force Acting on Biological Cells and Aggregates in Silicon Lab-on-chip

S. Burgarella[1], F. Maggioni[2], and G. Naldi[2]
[1]STMicroelectronics, Agrate Brianza, Milan, Italy
[2]Department of Mathematics, University of Milan, Milan, Italy

Dielectrophoresis is a method for cell manipulation in miniaturized devices exploiting the dielectric properties of cells and/or cellular aggregates suspended in a fluid and subjected to a high-gradient electric field. The mathematical expression of the force is obtained by a multipole ... Read More

Fluid Structure Interaction Applied to Upper Aorta Blood Flow

J. Anza[1], and M. Esteves[2]
[1]Department of applied mathematics, University of the Basque Country, Bilbao, Spain
[2]University of the Basque Country, Bilbao, Spain

This work deals with the computer simulation of the blood flow, the arterial wall deformation and their 3D bidirectional interaction, including initial stresses and root displacements. The flow is laminar and steady with flexible walls modeled with a hyperelastic Demiray material ... Read More

Extending Engineering Simulations to Scientists: Food Safety and Quality Prediction Using COMSOL Multiphysics® and LiveLink™ for Excel®

A. Warning[1], A. K. Datta[1]
[1]Cornell University, Ithaca, NY, USA

The objective of this study was to develop an easy to use interface in Excel® that connects to not only the solvers in COMSOL Multiphysics®, but also existing databases of food properties, foodborne pathogenic microorganisms kinetics, and chemical kinetics, creating a comprehensive ... Read More

Simulation of Normal and Cancerous T-cell Membrane Electroporation new

O. Henao[1], V. Gómez[1], I. De la Pava[1], J. Sánchez[1]
[1]Grupo Fisiología Celular y Aplicada, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia

Electroporation is an increase of the cell membrane permeability due to the formation of aqueous pores in it when the cell is under the influence of an intense electric field [1][2]. The formation of such pores in the membrane can be used to enhance the uptake of chemotherapeutic drugs ... Read More

Passive and Active Deformation Processes of 3D Fibre-Reinforced Caricatures of Cardiovascular Tissues

A. Di Carlo[1], P. Nardinocchi[2], T. Svaton[3], and L. Teresi[1]

[1]Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
[2]Dept. of Structural & Geotechnical Engineering, Università di Roma La Sapienza, Roma, Italy
[3]Dept. of Mathematics, University of West Bohemia, Pilsen, Czech Republic

In this paper, we present a mathematical model of contractile elastic solids meant to simulate various districts of the cardiovascular system, and based on the concepts of active deformation and embedded muscle fibres. Specifically, here we deal with the modeling of the gross mechanics ... Read More

Lowering of the Interstitial Fluid Pressure as a Result of Tissue Compliance Changes during High Intensity Focused Ultrasound Exposure: Insights from a Numerical Model

E. Sassaroli[1], B. O'Neill [1]
[1]The Methodist Hospital Research Institute, Houston, TX, USA

Interstitial fluid pressure (IFP) is elevated in tumors. Owing to this elevated IFP, the interstitial fluid velocity (IFV) is negligible throughout the tumor but significant near the tumor margin. Any therapeutic strategy that can lower IFP will improve drug convection within the tumor ... Read More

Finite Element Analysis of Induced Electroosmotic Flow in Brain Tissue and Application to ex vivo Determination of Enzyme Activity

Y. Ou[1], A. Rupert[1], M. Sandberg[2], S. Weber[1]
[1]University of Pittsburgh, Pittsburgh, PA, USA
[2]University of Gothenburg, Gothenburg, Sweden

Ectopeptidases are commonly accepted to be a means of clearing active peptides. However, studies have shown that they can also regulate peptide activity. We have developed a technique of electrokinetic push-pull perfusion (Ek-PPP, Figure 1) to examine this largely unexplored mechanism of ... Read More

A Multiscale-Multiphysics Model for Axon Pathfinding Simulation, the Example of the Olfactory System

G. Naldi[1], G. Aletti[1], P. Causin[1]
[1]Dipartimento di Matematica ‘F. Enriques’, Università degli Studi di Milano, Milano, Italy

In the developing embryo, neurons form connections by projecting axons to appropriate target areas. The projection process includes neurite elongation, resulting from the assembly of new cytoskeletal material at the free end of the axon, a complex cascade of steering decisions, driven by ... Read More

Deformable Image Registration for Pleural Photodynamic Therapy

B. Liu[1], T. C. Zhu[1]
[1]Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Deformable image registration is a form of medical image processing that can provide insights into the development of phenomenon and variation in normal anatomical structure over time. Prior to post-operative pleural photodynamic therapy (PDT), a series of CT scans of lungs will be ... Read More

Multiphysics Modelling and Simulation of Implantable Wireless MEMS Capacitive Sensor for Cardiovascular Diagnostics

R.Yogeswari[1], S.Venkateshwaran [1], K.Umapathi[1]
[1]United Institute of Technology,Coimbatore,Tamil Nadu, India

Monitoring the Central aorta is a more effective way to diagnose cardiovascular diseases than conventional techniques. Approximately, six million people in the world are currently living with aortic aneurysm and every year 750,000 new cases are diagnosed. This paper presents the design ... Read More