B. Boulbène, J. Morchain, and P. Schmitz
Université de Toulouse, NSA, UPS, INP, LISBP, Toulouse, France
We present numerical results involving microorganisms adhering to a plane surface submitted to a shear flow. The purpose is to have a better understanding of the removal mechanisms occurring during the cleaning in place of food processing equipments. The biological cell, i.e. the microorganism, is modelled as a rigid obstacle embedded in the bottom wall of the fluid domain. Shear induced ...
Advancing Regulatory Science through Integrative Engineering with COMSOL Multiphysics® Software Modeling
G. Zhang 
 Department of Bioengineering, Institute for Biological Interfaces of Engineering, Clemson University, Clemson, SC, USA
The US Food and Drug Administration (FDA) faces significant challenges in its regulatory approval processes due to a lack of relevant science, and many practices are limited by laws enacted in the previous century . Therefore, in recent years, the FDA has identified the need for advancements in regulatory science and innovation. In a broader sense, advancing regulatory science is not just ...
O. Nicotra, and A. La Magna
CNR-IMM Sezione di Catania, Catania, Italy
One of the major applications for dielectrophoresis is the selective trapping and fractionation in lab-on-a-chip devices. Nevertheless, many-particle effects due to high concentrations of biological material around electrodes can cause a rapid decrease of trapping efficiency in dielectrophoretic devices. In this contribution we present a new approach based on a drift-diffusion dynamics to study ...
A. Candeo and F. Dughiero
Department Electrical Engineering, University of Padova, Padova, Italy
Radiofrequency Ablation (RFA) represents a valid alternative for treating liver metastases in medically complicated patients. Conventional devices currently operate at 500 kHz, due to good conducting properties of tissues. However, the use of lower frequencies (i.e. 20 kHz) has been recently reported to enhance the treatment effectiveness, due to a more pronounced difference in electrical ...
An Elastic and Hyperelastic Material Model of Joint Cartilage - Calculation of the Pressure Dependent Material Stress in Joint Cartilage
T. Reuter, and M. Hoffmann
Research Centre of Medical Technology and Biotechnology
Bad Langensalza, Germany
In this paper we introduce a elastic and hyperelastic model to describe the pressure dependent material stress in joint cartilage. We used the pressure dependent E-modulus E = f(s) to calculate the material stress. E = f(s) is a degree 4 polynomial . The indentor was pressed 0.4 mm into the tissue. The results show that the maximal stress at the contact zone between indentor and cartilage ...
R. Sikorski, B. Chapman, T. Merrill
Rowan University, Glassboro, NJ, USA
A CFD cardiac catheter model was developed to determine the potential for blood hemolysis during administration of local therapeutic hypothermia using a CoolGuide catheter. In vivo animal studies have shown that mild hypothermia may reduce reperfusion injury often associated with heart attack. The CoolGuide Catheter System (CCS) delivers rapid local cooling through a cardiac catheter, reducing ...
S. Nikolaev, A. Trubuil
Institute of cytology and genetics SB RAS, Novosibirsk, Russia
Institut National de la Recherche Agronomique, Jouy-en-Josas, France
We used a predefined COMSOL Multiphysics® interface to imitate biological growth and shape change (morphodynamics). We found a set of parameters that supply observed morphodynamics for an Arabidopsis embryo during its transition from globular to heart stage.
D. R. M. Vieira , S. A. Cardoso , A. S. Santos ,
 Universidade Federal do Pará, Pará, Brasil
A biotransformação de substratos utilizando enzimas imobilizadas em nanopartículas presentes num meio fluido (substrato), contido num bioreator CSTR, foi investigada. O software COMSOL Multiphysics foi usado para simular o sistema através do uso das equações de difusão de espécies apropriadas para o consumo do substrato. Nessa investigação, a difusão na superfície da nanopartícula, onde ocorre a ...
D. Iber, D. Menshykau, and P. Germann
Department of Biosystems Science and Engineering
Organogenesis is a tightly regulated process that has been studied experimentally for decades. Computational models can help to integrate available knowledge and to better understand the underlying regulatory logic. We are currently studying mechanistic models for the development of limbs, lungs, kidneys, and bone. We have tested a number of alternative methods to solve our spatio-temporal ...
M.S. Yeoman, A. Cizinauskas, C. Lowry, G. Vincent, S. Collins, D. Simpson
Continuum Blue, Tredomen, Ystrad Mynach, United Kingdom
Corin Group, Cirencester, United Kingdom
Imoprhics, Manchester, United Kingdom
Bone resorption around hip stems, in particular periprosthetic bone loss, is a common observation post-operatively. A number of factors influence the amount of bone loss over time and the mechanical environment following total hip replacement (THR) is important. Conventional long stem prostheses have been shown to transfer loads distally, resulting in bone loss of the proximal femur. More ...