Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

An Elastic and Hyperelastic Material Model of Joint Cartilage - Calculation of the Pressure Dependent Modulus of Elasticity by Comparison with Experiments and Simulations

T. Reuter, and M. Hoffmann
fzmb GmbH
Research Centre of Medical Technology and Biotechnology
Bad Langensalza, Germany

In this paper we introduce a elastic and hyperelastic model to describe the biomechanics of joint cartilage. As biomechanical property we calculated the pressure dependent E-modulus E = f(s) to describe the dependence of the biomechanical properties on pressure. The calculation based on the comparison and the iterative approach of the force-way-functions between the experiments and ...

An Elastic and Hyperelastic Material Model of Joint Cartilage - Calculation of the Pressure Dependent Material Stress in Joint Cartilage

T. Reuter, and M. Hoffmann
fzmb GmbH
Research Centre of Medical Technology and Biotechnology
Bad Langensalza, Germany

In this paper we introduce a elastic and hyperelastic model to describe the pressure dependent material stress in joint cartilage. We used the pressure dependent E-modulus E = f(s) to calculate the material stress. E = f(s) is a degree 4 polynomial . The indentor was pressed 0.4 mm into the tissue. The results show that the maximal stress at the contact zone between indentor and cartilage ...

Numerical Homogenization in Multi-scale Models of Musculoskeletal Mineralized Tissues

A. Gerisch[1], S. Tiburtius[1], Q. Grimal[2], and K. Raum[3]
[1]Technische Universität Darmstadt, Darmstadt, Germany
[2]Laboratoire d’Imagerie Paramétrique, UPMC, Paris, France
[3]Julius Wolff Institut & Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany

Musculoskeletal mineralized tissues (MMTs), e.g. bone, are hierarchical composite materials. Their effective elastic properties at different scales are of interest for computational studies of the MMT’s response to mechanical loading but also to realistically simulate implant osseointegration. We combine multi-scale and multi-modal experimental techniques with mathematical modelling of MMTs ...

Homogenized models of electrically-coupled excitable tissues

P. Goel


Pranay Goel received his B. Tech. in Engineering Physics from IIT Bombay, and MS and PhD in Physics from the University of Pittsburgh in 2003. He went on to two postodoctoral positions, the first at the Mathematical Biosciences Institute, The Ohio State University, and another at the Laboratory of Biological Modeling, The U.S. National Institutes of Health. He has been with IISER Pune since ...

Drug Distribution in the Human Eye

L. Murtomäki[1], T. Kainuvaara[1]
[1]University of Helsinki, Helsinki, Finland

Drug therapy of the posterior segment of an eye is very challenging due to the difficult accessibility. Modern drugs often are large molecules, such as peptides, antibodies or oligonucleotides which are administrated, e.g. by intravitreous injections which requires clinical conditions. Computer modeling can be helpful in designing new and less invasive routes of drug administration. COMSOL is ...

Simulation of a Magnetic Induction Method for Determining Passive Electrical Property Changes of Human Trunk Due to Vital Activities

H. Mahdavi[1], J. Rosell Ferrer[1]
[1]Universitat Politècnica de Catalunya, Barcelona, Spain

The human body consists of many different types of tissues each with specific passive electrical properties. Vital activities lead to a characteristic change of these properties and geometrical changes. Magnetic induction is a non-contact method which can be used to determine these changes. The method is based on the creation of a primary magnetic field that will produce eddy currents in the ...

Downscale Finite Element Modeling of Aortic Valve Leaflets for In-Situ Estimation of Cell Level Mechanics

R. Buchanan[1], M. Sacks[1]
[1]Institute for Computational Engineering and Sciences, Department of Biomedical Engineering, University of Texas, Austin, TX, USA

As in all tissues, mechanical forces in the aortic valve (AV) modulate the constituent cell population’s physiology and biosynthetic activity. While advances have been made toward the understanding of this complex multi-scale relationship, the specific role that and extracellular matrix (ECM) coupling plays on the mechanical response of the AV interstitial cell (AVIC) is poorly understood. The ...

Deposition of Submicron Charged Spherical Particles in the Trachea of the Human Airways

H.O. Åkerstedt[1]
[1]Luleå University of Technology, Luleå, Sweden

This paper presents a numerical study of the deposition of submicron charged spherical particles caused by convection, Brownian and turbulent diffusion in a pipe with a smooth wall and with a cartilaginous ring wall structure (see figure). The model is supposed to describe deposition of charged particles in generation 0 (trachea) of the human lung.The problem is defined by solving the fluid flow ...

Can Oscillatory Convection Accelerate Signal Propagation in Simple Epithelium?

M. Nebyla[1], M. Pribyl[1]
[1]Institute of Chemical Technology, Prague, Department of Chemical Engineering, Prague, Czech Republic

We introduce a mathematical model of signal transmission in simple epithelial layers. The mathematical model consists of reaction-transport equations for extracellular ligands, cellular receptors, ligand-receptor complexes and a ligand releasing protease. We consider diffusion and nonstationary convective transport of protein ligands in the extracellular space. The study was carried out using ...

Optimization of 3D Layered Metal-Dielectric Stacks (MDS) for Near-Field Fluorescence Imaging

P.S. Tan[1], K. Elsayad[2], K. Heinze[1]
[1]Rudolf Virchow Center, University of Würzburg, Würzburg, Germany
[2]Research Institute of Molecular Pathology (IMP), Vienna, Austria

Nano-structures consisting of layered metal-dielectric stacks (MDSs) can be designed to have evanescent transmission and reflection coefficients that oscillate as a function of transverse wavevector and frequency. However, these structures always suffer from the material losses and surface roughness that are detrimental to image reconstruction. As such, we propose an optimized planar anisotropic ...