See How Multiphysics Simulation Is Used in Research and Development

Engineers, researchers, and scientists across industries use multiphysics simulation to research and develop innovative product designs and processes. Find inspiration in technical papers and presentations they have presented at the COMSOL Conference. Browse the selection below or use the Quick Search tool to find a specific presentation or filter by application area.
View the COMSOL Conference 2019 Collection
Bioscience and Bioengineeringx

Combining Image-Based Solutions with COMSOL Multiphysics® Simulations

D. Harman[1]
[1]Synopsys Simpleware, United Kingdom

Models generated from 3D image data (such as MRI or CT) are used in COMSOL Multiphysics® to analyse real-world problems and gain insights into biomechanical and industrial processes. We work with customers from different areas, from Life Sciences to Materials Science, to implement ... Read More

Finite Element Analysis of TTFields in Brain Metastasis According to Various Types of Cerebral Edema

S. Pisati[1], P. San[1], E. Lok[1], E. Wong[1]
[1]Beth Israel Deaconess Medical CEnter, USA

Background: TTFields are being investigated for treatment of brain metastasis. Although vasogenic edema is the most common type of associated cerebral edema, other forms of edema might arise within the brain due to prior treatment or other confounding effects. Therefore, we seek to ... Read More

Modeling Fluid-Structure Interaction of Biodegradation in Engineered Tissue Scaffolds

P. Patki[1], F. Costanzo[1]
[1]Pennsylvania State University, USA

Biodegradable scaffolds are often inserted in the body, to provide mechanical support to recovering broken or damaged tissues. Monitoring the degradation chemistry and mechanical response of these scaffolds is important: their degradation rate should match tissue regeneration rate, while ... Read More

Keratin Biomaterial Diffusivity Determination in a 1D-Like Channel using COMSOL Multiphysics® and MATLAB®

E. Civetti[1], V. Khaimov[1], R. de Guzman[1]
[1]Hofstra University, USA

Introduction: Keratin protein biomaterials (KTN) are used in various tissue engineering applications including liquid infusions and gel implants. Random movement of molecular species is characterized by Fick’s laws of diffusion (and velocity-dependent convection) with the ... Read More

Growth Mode Selection of Radially Growing Turing Patterns

N. Somberg[1], C. Konow[1], M. Dolnik[1], I. Epstein[1]
[1]Brandeis University, USA

In his seminal work, “A Chemical Basis for Morphogenesis,” Alan Turing proposed a mechanism for pattern formation in nature. Turing patterns occur in a broad range of natural systems, from desert vegetation to animal markings. Turing mechanisms have also been implicated in processes ... Read More

Analysis of PhotoThermal Ablation

L. De Taboada[1], J. Crompton[2], K. Koppenhoefer[2], S. Yushanov[2]
[1]LiteCure, USA
[2]AltaSim Technologies, USA

Cancer cells have an increased sensitivity to heat compared to healthy cells; at 42°C cancer cells are destroyed while normal cells can survive up to 47°C. Thus hyperthermia-based approaches that target specific spatial locations and simultaneously provide controlled thermal exposure ... Read More

COMSOL Multiphysics® Model for Optimizing Regeneration of CFP Catalyst in Packed-Bed Reactors

B. Adkins[1], J. Parks II[1], K. Iisa[2], K. Smith[2]
[1]Oak Ridge National Laboratory, USA
[2]National Renewable Energy Laboratory, USA

The DOE BETO consortium "ChemCatBio" has developed a packed bed catalyst for use in a Catalytic Fast Pyrolysis (CFP) process for producing biofuels and chemicals from lignocellulosic biomass. Another BETO consortium known as "CCPC"  (Consortium for Computational Physics and Chemistry) is ... Read More

A Mathematical Model of Cerebral Cortical Folding Development

A. Kilinc[1]
[1]Florida State University, USA

The setup of the problem: To develop a mathematical model of cerebral cortical folding development, half-hemisphere geometry is used and the outer layer (gray matter) is allowed to move inward under the effect of both physical and biochemical factors. The model is time-dependent, ... Read More

Computational Modeling of Nanoparticle Heating for Treatment Planning of Plasmonic Photothermal Therapy in Pancreatic Cancer

S. Manrique-Bedoya[1], C. Moreau[2], S. Patel[2], Y. Feng[1], K. Mayer[1]
[1]University of Texas at San Antonio, USA
[2]UT Health San Antonio, USA

Pancreatic cancer is one of the deadliest cancers, with a 7% survival rate at five years from diagnosis. The limited number of treatment options for patients who are diagnosed with late-stage disease is a major contributor to this problem. Therapeutic modalities such as radiofrequency ... Read More

Modeling a Human Microfluidic Glomerulus and Proximal Tubule-On-A-Chip

S. Zhang[1], G. Mahler[1]
[1]Binghamton University, State University of New York, USA

Introduction: Discovering therapeutic drugs that target renal disease is a challenge due to the adverse effects not detected until late in drug development [1]. Preclinical drug studies in animals and static human cell cultures fail to characterize <em>in vivo</em> renal ... Read More