A. Heidsieck, and B. Gleich
Zentralinstitut für Medizintechnik, TU München, München, Germany
The technique of magnetic drug targeting binds genetic material or drugs to superparamagnetic nanoparticles and accumulates them via an external magnetic field in a target region. However, it is still a challenge for this approach to succeed in areas with high flow rates, like the aorta or the heart ventricle. The magnetic field sources have to be accurately optimized and adapted to the local ...
Compensating Spatial Variability of Quantity Index in 2D Electrical Impedance Tomography: COMSOL Multiphysics Study
S. Oh, and R. Sadleir
Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA
In Electrical Impedance Tomography (EIT), an array of surface electrodes is used to inject current and measure the resulting voltages to non-invasively obtain conductivity distributions of objects. The system can be easily implemented as a device that monitors hemorrhage, respiration, gastric emptying or brain activities.The Quantity Index (QI), an integral measure of reconstructed images, can be ...
C. Gavrila, A. Ghiaus, and I. Gruia
Technical University of Civil Engineering Bucharest, Faculty of Building Services, Bucharest, Romania
University of Bucharest, Faculty of Physics, Bucharest, Romania
A dynamic mathematical model, based on physical and transport properties and mass and energy balances, was developed for the simulation of unsteady convective drying of agricultural products (fruits and vegetables) in static bed conditions. The model utilizes water sorption isotherm equations and the change in solid density due to the shrinkage phenomenon. The aim of this article is to describe ...
Numerical Investigation of a Time-dependent Magnetic Actuation Technique for Tagging Biomolecules with Magnetic Nanoparticles in a Microfluidic System
A. Munir, J. Wang, Z. Zhu, and H.S. Zhou
Worcester Polytechnic Institute, Worcester, MA, USA
The magnetic body forces that act on mono-dispersed magnetic nanoparticles (MNPs) tagged biomolecules in a microfluidic system can be efficiently used in various applications that involve separation and detection including DNA and protein analysis, bio-defense, drug delivery, and pharmaceutical development. In this work, we report an FEM model to demonstrate a novel method of tagging biomolecules ...
T. Shazly, and J. Ferdous
Biomedical Eng., Mechanical Eng. Dept.
University of South Carolina
Erodible polymeric scaffolds can mitigate long-term risks associated with permanent implants currently used to treat ischemic artery disease. However, safe deployment of erodible scaffolds is predicated on understanding the interactions between evolved material by-products and local biological tissues. We developed an integrated computational model of polymeric scaffold degradation, by-product ...
J.J. Dubowski, and D.Carrier
Department of Electrical and Computer Engineering, Université de Sherbrooke, Quebec, Canada
We present a Finite Element Method simulation procedure that allows rapid development of prototype devices comprising novel self-referenced interference SPR (surface plasmon resonance) biosensing microstructures. The procedure takes advantage of COMSOL Multiphysics and MATLAB software and their bi-directional link. The simulation is made using COMSOL RF Module, 2D harmonic propagation ...
Image-based Simulation of Electrical Impedance Techniques Applied on the Human Thorax for Cardio-pulmonary Applications
A. Harkara, R.M. Heethaar, R.T. Cotton, and F.K. Hermans
Simpleware Ltd., Exeter, UK
VU University Medical Center, Amsterdam, Netherlands
For medical diagnostic purposes there is an increasing need for non-(or minimal) invasive techniques to measure all kinds of parameters that can provide insight in the functioning of cells, organs or organ systems. Currently, Impedance Cardiography (ICG) is used for measurements of the heart and Electric Impedance Tomography (EIT) is used for investigating lung tissue condition. The PDE is ...
K. Manda, and A. Eriksson
Royal Institute of Technology
100 44 Stockholm, Sweden
Articular cartilage is an avascular connective soft tissue in the diarthrodial joints and functions in a highly demanding mechanical environment. The degeneration or wear of the cartilage is a huge problem that effects millions of people every year. The long term objective of the present work is to develop an analytical articular cartilage growth model. A simplified 2D axisymmetric ...
S. Raveendran, S. Sukuvihar, S. Kumar, and T. Maekawa
• Bionanotechnology is a stream of modern science that deals with the study of biotechnology & nanotechnology applications. • Drug delivery applications as a key area of research attains more critical approaches where the role of nanoparticles are inevitable. • Biocompatible, non-cytotoxic hybrid mauran- chitosan nanoparticles has been synthesized and the drug release kinetics were ...
S. Mackintosh, J. Rodgers, S.P. Blythe
Lifescan Scotland, Inverness, Scotland
This paper describes the modeling of a blood glucose sensor using COMSOL Multiphysics. Chemical species interaction and diffusion, coupled with electrochemical oxidation of multiple blood species produced a powerful working model used in developing and refining a range of blood glucose sensors for the commercial market.